Growth hormone · blend vial · GHRH analog for GH/IGF-1 research
CJC-1295 / Ipamorelin Blend
Modified GRF 1-29, Mod GRF 1-29, CJC-1295 no DAC, CJC-1295 DAC
A GHRH analog sold with or without DAC. Both forms exist: DAC albumin-binding stretches half-life to days; no-DAC (Mod GRF 1-29) stays a pulse. NovaEvum’s vial is the no-DAC + Ipamorelin blend. Literature score 40/100. FDA has flagged cardiac-event risk in this class.
- GH release
- Recovery
- Sleep
- Catalog fill
- 5 mg + 5 mg
- Typical water
- 2 mL
- Route
- Subcutaneous
- Cycle
- 8–12 weeks.
- Approval
- Not FDA-approved. No recent trials that led to a licence.
- Status
- Research chemical. WADA prohibited. 2024 compounding review is not approval.
- Evidence
- Early-phase work before 2020. Nothing that became a product.
- Research score
- 40 / 100
Mechanism
GHRH-receptor drive of pituitary GH. DAC (maleimidopropionic acid) binds albumin (~6–8 day half-life). The catalog blend is the short analog plus Ipamorelin, not weekly DAC.
Safety file
Long-term human safety unknown. FDA notes cardiac-event risk. GH/IGF-1 elevation can mean water retention and insulin resistance.
- Injection-site reactions
- Numbness
- Water retention
- Headache
- Joint stiffness
- Insulin resistance
Reconstitution
2 mL bacteriostatic water yields 2.5 mg/mL of each peptide. A 100 mcg-of-each pulse is 4 units; 200 mcg of each is 8 units.
Research amounts
1–2 pulses daily, often evening. No-DAC CJC is short-acting, so it is pulsed, not weekly.
| Step | Amount | Frequency | Notes |
|---|---|---|---|
| Standard pulse | 100 mcg each | 1–2× daily | 4 units from a 2 mL reconstitution |
| Higher pulse | 200 mcg each | 1–2× daily | 8 units |
Storage
- Lyophilized
- −20 °C freezer preferred; a refrigerator is also acceptable. Do not open a cold vial — wait 15–30 minutes so it does not sweat. Avoid freeze–thaw cycling.
- After water
- 2–8 °C, dark, up to 45 days when mixed with bacteriostatic water. Mixed vials stay in their box. Sterile water (no preservative) is single-use.
Worksheet notes
- You cannot change the CJC:Ipamorelin ratio from this vial.
- Do not also run a separate Ipamorelin vial on the same days unless you intend to raise only the secretagogue.
- Bacteriostatic water: 20–25 °C. Do not refrigerate the diluent.
- Amounts on this sheet are reconstitution math for the vial, not a recommendation.
Full protocol
Titration, schedule, and handling
The complete protocol for CJC-1295 / Ipamorelin Blend. Where it differs from the worksheet amounts above, the worksheet reflects the NovaEvum vial.
Reconstitution
| Vial | 2 mL water | 3 mL water |
|---|---|---|
| 10 mg | 5 mg/mL | 3.33 mg/mL |
The classic GH pairing of CJC-1295 (No DAC) and Ipamorelin in a 1:1 ratio. The 10 mg vial holds 5 mg of each. Doses below are stated per peptide (they always move together); the calculator works in total blend mg, so 0.2 mg of each peptide is 0.4 mg of total blend.
- Use bacteriostatic water as the diluent.
- Add the water slowly, letting it run down the inside wall of the vial rather than onto the powder.
- Swirl gently to mix, then leave it to dissolve. Do not shake.
- Give it a few minutes. The finished solution should be clear and colourless.
Protocol
Route: Subcutaneous
Why these two together
- CJC-1295 (No DAC) tells the pituitary to make growth hormone, while Ipamorelin tells it to release it: two different signals on the same gland
- The No DAC version is used because its short half-life lines up with Ipamorelin, which keeps the natural pulsing pattern intact
- They are combined in one syringe and one shot
Standard protocol (subcutaneous)
- 0.1 mg of each peptide before bed is the standard starting dose, moving to 0.2 mg of each for most people
- On the 10 mg vial (5 mg of each) at a 2 mL fill, 0.1 mg of each is a 0.04 mL draw (4 units) and 0.2 mg of each is 0.08 mL (8 units)
- Dose once daily, 5 days on, 2 days off
Timing matters
- Inject before bed, at least 2 hours after your last meal
- Food (especially carbs and fat) blunts the GH pulse, and the body releases its own GH overnight, so a fasted bedtime shot lines up with natural timing
- A fasted morning or post-workout dose is the other common slot
Titration and ceiling
- Start at 0.1 mg of each and increase by about 0.05 mg every 1 to 2 weeks if you want, up to a common ceiling of 0.3 mg of each per day (0.12 mL / 12 units at the 2 mL fill)
- 0.1 mg is already a saturating dose for many, so more is not always better
Dosing detail
- 0.1 mg of each peptide is the standard start, 0.2 mg of each suits most people, 0.3 mg of each is a common ceiling.
- At the 2 mL fill: 0.1 mg of each is 0.04 mL (4 units), 0.2 mg is 0.08 mL (8 units), 0.3 mg is 0.12 mL (12 units).
- Inject once daily before bed, fasted (2 hours after eating), 5 days on and 2 off.
- Both peptides are short-acting and share one syringe, so the pairing keeps the natural pulsatile GH release.
Duration
- Run 8 to 12 weeks (extend to 16 if desired), 5 on / 2 off, then a break.
Notes
- The most common GH peptide pairing.
- One daily shot covers both peptides instead of running two separate vials.
- A brief flush after injecting is common and harmless. Inject subcutaneously and rotate sites.
Storage and handling
- Keep the powdered (lyophilized) vial in a cool, dark place. Refrigerate it for longer-term storage before mixing.
- Once reconstituted and refrigerated at 2–8 °C away from light, use the vial within 90 days.
- Do not freeze a reconstituted vial, and keep it away from heat and sunlight.
- If the solution turns cloudy, develops floating particles, or shows any other sign of degradation, stop using that vial.