Skin, hair & aesthetics · FDA-approved HSDD in premenopausal women (Vyleesi)
PT-141
Bremelanotide, Vyleesi
Bremelanotide, a Melanotan II descendant. The approved drug is Vyleesi: central MC4R, not a PDE5/blood-flow drug. Nausea is common (~40%). Contraindicated in uncontrolled hypertension/CVD.
- Sexual desire (labelled population)
- MC4R agonist
- Catalog fill
- 10 mg
- Typical water
- 2 mL
- Route
- Subcutaneous
- Cycle
- Not a cycling compound. Limit frequency; do not treat it as a daily peptide.
- Approval
- FDA-approved 2019 for premenopausal HSDD.
- Status
- FDA-approved prescription (Vyleesi) for a specific indication.
- Evidence
- Labelled melanocortin agonist with an approved indication.
- Research score
- 90 / 100
Mechanism
MC4R in CNS pathways for sexual desire and arousal; dopaminergic and related cascades — not a local vasodilator.
Safety file
Nausea very common. Flushing, headache, transient BP rise. Focal hyperpigmentation with frequent use. Do not use in uncontrolled hypertension or CVD.
- Nausea
- Flushing
- Injection-site reactions
- Headache
- Vomiting
- Transient BP rise
Reconstitution
2 mL bacteriostatic water yields 5 mg/mL. A 1 mg amount is 20 units.
Research amounts
As needed, not daily. Allow several hours of observation after a first small amount.
| Step | Amount | Frequency | Notes |
|---|---|---|---|
| First research amount | 0.5–1.0 mg | As needed | 10–20 units from a 2 mL reconstitution |
| Upper cited amount | 1.5–2.0 mg | As needed | 30–40 units |
Storage
- Lyophilized
- −20 °C freezer preferred; a refrigerator is also acceptable. Do not open a cold vial — wait 15–30 minutes so it does not sweat. Avoid freeze–thaw cycling.
- After water
- 2–8 °C, dark, up to 45 days when mixed with bacteriostatic water. Mixed vials stay in their box. Sterile water (no preservative) is single-use.
Worksheet notes
- Flushing, nausea, and blood-pressure changes are commonly reported in the literature. Start at the low end.
- This is not a substitute for medical evaluation of sexual or cardiovascular symptoms.
- Bacteriostatic water: 20–25 °C. Do not refrigerate the diluent.
- Amounts on this sheet are reconstitution math for the vial, not a recommendation.
Full protocol
Titration, schedule, and handling
The complete protocol for PT-141. Where it differs from the worksheet amounts above, the worksheet reflects the NovaEvum vial.
Reconstitution
| Vial | 2 mL water | 3 mL water |
|---|---|---|
| 10 mg | 5 mg/mL | 3.33 mg/mL |
- Use bacteriostatic water as the diluent.
- Add the water slowly, letting it run down the inside wall of the vial rather than onto the powder.
- Swirl gently to mix, then leave it to dissolve. Do not shake.
- Give it a few minutes. The finished solution should be clear and colourless.
Protocol
Route: Subcutaneous, on demand
Standard protocol (subcutaneous, on demand)
- 1 mg to 2 mg, taken at least 45 minutes before activity, not on a daily schedule
- Start at the low end (1 mg) the first time to gauge nausea
- At a 2 mL fill on a 10 mg vial (5 mg/mL), 1 mg is a 0.2 mL draw (20 units)
Use occasionally, do not stack
- This is an as-needed peptide, not a daily one
- Do not combine with Melanotan-2 or Melanotan-1; they act on the same melanocortin system
- Space doses out; it is not meant for back-to-back daily use
Dosing detail
- 1 mg to 2 mg, about 45 minutes before activity. Used on demand, not daily.
- Start at 1 mg to assess nausea, which is the main side effect, along with facial flushing.
- Works through the nervous system for libido rather than on blood flow like the ED drugs.
- Do not stack with MT-2 or MT-1 (same receptor family).
Duration
- Used occasionally, on demand, rather than in a continuous cycle.
Notes
- Also called bremelanotide. Works on the nervous system for libido rather than on blood flow.
- Nausea and facial flushing are the common effects and ease at lower doses.
- Inject subcutaneously.
Storage and handling
- Keep the powdered (lyophilized) vial in a cool, dark place. Refrigerate it for longer-term storage before mixing.
- Once reconstituted and refrigerated at 2–8 °C away from light, use the vial within 90 days.
- Do not freeze a reconstituted vial, and keep it away from heat and sunlight.
- If the solution turns cloudy, develops floating particles, or shows any other sign of degradation, stop using that vial.