Library · Muscle, bone & joint · Muscle repair and growth enhancement
MGF (Mechano Growth Factor, IGF-1Ec)
IGF-1Ec, IGF-IEb, Mechano-sensitive Growth Factor, MGF peptide
MGF, also known as IGF-1Ec, is an IGF-1 splice variant produced in muscle after mechanical strain or injury. It aids local repair and hypertrophy by activating satellite cells. Synthetic, often PEGylated, versions are used in muscle-regeneration research.
Research score 35/100. Reference only, not a dose.
- Muscle Growth
- Recovery Enhancement
- Healing
- Stem Cell Activation
- Joint Support
- US status
- Research Chemical
- Approval
- Research Chemical Only
- Evidence
- No specific human clinical trials found (2020-2025). Preclinical tissue repair studies.
- Research score
- 35 / 100
- Indication
- Muscle Wasting
- Origin
- UK
- Source category
- Muscles & Joints
- Status group
- Research chemical
Mechanism
Distinct from systemic IGF-1, it drives satellite-cell proliferation and migration via PI3K/Akt signaling and supports protein synthesis through mTOR, with expression peaking 24–72 hours after mechanical stimulation.
Safety file
Human safety data are absent; theoretical cancer risk is assumed by analogy with IGF-1.
- Injection site reactions
- Temporary numbness at injection site
- Potential water retention