Longevity & cellular · Circadian rhythm regulation and anti-aging effects
Epitalon
5–10 mg daily, 10–20 day course
Synthetic tetrapeptide (Ala-Glu-Asp-Gly) developed by Vladimir Khavinson’s institute in the 1980s to mimic pineal peptide epithalamin. Studied in Russia for effects on melatonin release, circadian rhythm, and cellular aging via telomerase activity; not approved in Western markets, with no rigorous Western clinical trials.
Reconstitution
| Vial | 2 mL water | 3 mL water |
|---|---|---|
| 50 mg | 25 mg/mL | 16.67 mg/mL |
- Use bacteriostatic water as the diluent.
- Add the water slowly, letting it run down the inside wall of the vial rather than onto the powder.
- Swirl gently to mix, then leave it to dissolve. Do not shake.
- Give it a few minutes. The finished solution should be clear and colourless.
Protocol
Route: Subcutaneous
Standard protocol (subcutaneous)
- 5 mg to 10 mg per day, once daily, run as a defined course
- At a 2 mL fill on a 50 mg vial (25 mg/mL), 5 mg is a 0.2 mL draw (20 units) and 10 mg is 0.4 mL (40 units)
The classic course
- Run daily for 10 to 20 consecutive days, then stop
- This single course is typically repeated only 1 to 2 times per year, since the effects are described as lasting well beyond the course itself
Dosing detail
- Common dose is 5 mg to 10 mg per day during the course.
- A telomere- and longevity-focused bioregulator peptide.
- Run as a 10 to 20 day course, then a long break. Not a continuous daily peptide.
- Generally well tolerated.
Duration
- A 10 to 20 day daily course, repeated only once or twice a year.
Notes
- A telomere- and longevity-focused bioregulator peptide.
- Generally well tolerated.
- Inject subcutaneously and rotate sites.
Storage and handling
- Keep the powdered (lyophilized) vial in a cool, dark place. Refrigerate it for longer-term storage before mixing.
- Once reconstituted and refrigerated at 2–8 °C away from light, use the vial within 90 days.
- Do not freeze a reconstituted vial, and keep it away from heat and sunlight.
- If the solution turns cloudy, develops floating particles, or shows any other sign of degradation, stop using that vial.