GLP-1 & metabolic · Skin regeneration and photoprotection
SLU-PP-332
0.5–1 mg daily
A novel synthetic agonist targeting estrogen-related receptors alpha, beta, and gamma, often described as an 'exercise mimetic' for its potential to raise metabolic endurance and preserve muscle function without exercise. It remains in preclinical development.
Important: SLU-PP-332 does not dissolve in bacteriostatic water alone. Dissolve it in DMSO first (about 10% of your final volume), then add bac water. For a 2 mL final fill: 0.2 mL DMSO first, then 1.8 mL bac water. Skipping the DMSO leaves it cloudy and undissolved.
Reconstitution
| Vial | 2 mL water |
|---|---|
| 5 mg | 2.5 mg/mL |
Not a normal peptide. Add DMSO first at about 10% of the target volume (0.2 mL for a 2 mL fill), swirl until the powder fully dissolves, then top up with 1.8 mL bac water to reach 2 mL total. Concentration is based on the 2 mL final volume.
- Use bacteriostatic water as the diluent.
- Add the water slowly, letting it run down the inside wall of the vial rather than onto the powder.
- Swirl gently to mix, then leave it to dissolve. Do not shake.
- Give it a few minutes. The finished solution should be clear and colourless.
- Add about 0.2 mL of DMSO (roughly 10% of a 2 mL final volume) to the vial first. Swirl gently until the powder is fully dissolved.
- Then add bacteriostatic water slowly down the wall (about 1.8 mL) to bring the total to 2 mL, swirling as you go.
- Do not shake. Gentle swirling or slow rotation only.
- If it stays cloudy, warm the closed vial in your hand for 60 to 90 seconds and swirl again. It should be clear before you draw a dose.
Protocol
Route: Subcutaneous
Standard protocol (subcutaneous)
- 0.5 mg to 1 mg per day, once daily
- Most start at 0.5 mg
- Mind the reconstitution warning above: it needs a co-solvent to dissolve before it can be dosed at all
Dosing detail
- Common dose is 0.5 mg to 1 mg per day, once daily.
- An ERR agonist that mimics some effects of exercise on metabolism.
- The dissolving step (co-solvent first, then bac water) is the part people get wrong, so get that right before worrying about dose.
- Human data is very limited, so conservative dosing and short blocks make sense.
Duration
- Run in 4 to 8 week blocks alongside training.
Notes
- An ERR agonist studied as an exercise mimetic for metabolism and endurance.
- The solubility quirk is the main thing to get right.
- Inject subcutaneously and rotate sites.
Storage and handling
- Keep the powdered (lyophilized) vial in a cool, dark place. Refrigerate it for longer-term storage before mixing.
- Once reconstituted and refrigerated at 2–8 °C away from light, use the vial within 90 days.
- Do not freeze a reconstituted vial, and keep it away from heat and sunlight.
- If the solution turns cloudy, develops floating particles, or shows any other sign of degradation, stop using that vial.