Library · Reproductive · Regulation of reproductive hormone function
Gonadorelin (GnRH)
GnRH, LHRH, Luteinizing hormone-releasing hormone, Factrel, Lutrelef
Synthetic gonadotropin-releasing hormone (GnRH), used diagnostically to test pituitary function and therapeutically — via pulsatile pump to induce ovulation, or via continuous agonist dosing to suppress sex hormones in conditions like endometriosis or prostate cancer.
Research score 85/100. Reference only, not a dose.
- Hormone Regulation
- Fertility Enhancement
- Reproductive Function
- GnRH Agonist
- US status
- Prescription Only
- Approval
- FDA Approved
- Evidence
- FDA Approved (Factrel). Used for fertility and precocious puberty.
- Research score
- 85 / 100
- Indication
- Multiple Approved Indications
- Origin
- USA
- Source category
- Reproductive System
- Status group
- Approved / prescription
Mechanism
Binds pituitary GnRH receptors, activating Gq/11 signaling to raise calcium and protein kinase C, triggering LH and FSH release that drives gonadal steroid production; pulsatile dosing sustains reproductive function, while continuous dosing desensitizes receptors and suppresses it.
Safety file
Safe for diagnostic use; therapeutic use risks hot flashes, long-term bone density loss, and injection-site pain.
- Headache
- Nausea
- Local injection site reactions
- Temporary hormonal fluctuations