Library · Digestive & liver · Pancreatic function support and regulation
Pancragen (Lys-Glu-Asp-Trp)
KEDW, Lys-Glu-Asp-Trp tetrapeptide, Pancreatic bioregulator peptide
A Russian-studied synthetic tetrapeptide (Lys-Glu-Asp-Trp) intended to support and regenerate pancreatic tissue, explored for type 2 diabetes and pancreatitis through aiding cell differentiation and insulin secretion.
Research score 40/100. Reference only, not a dose.
- Gut Health
- Anti-inflammatory
- Healing
- Metabolic Enhancement
- US status
- Research Chemical
- Approval
- Research Chemical Only
- Evidence
- Russian data. No FDA approval.
- Research score
- 40 / 100
- Indication
- Research Only - No Medical Indication
- Origin
- Russia
- Source category
- Digestive System
- Status group
- Research chemical
Mechanism
Binds pancreatic cell receptors to activate PI3K/Akt and EGF-receptor signaling, supporting protein synthesis and repair, while reducing inflammatory cytokines via NF-κB modulation and aiding beta-cell function.
Safety file
No established human safety data outside Russia; presumed low toxicity.
- Mild digestive discomfort
- Nausea
- Changes in appetite