Library · Digestive & liver · Anti-inflammatory and digestive system regulation
VIP (Vasoactive Intestinal Peptide)
Vasoactive Intestinal Polypeptide, VIP-28, Aviptadil
Vasoactive Intestinal Peptide is a natural 28-amino-acid hormone involved in digestion, immune regulation, and neurological function, acting as a potent vasodilator and anti-inflammatory. Its synthetic form, Aviptadil, has been studied for conditions including respiratory distress and holds Orphan Drug status for pulmonary arterial hypertension, available via compounding pharmacies.
Research score 80/100. Reference only, not a dose.
- Anti-inflammatory
- Gut Health
- Immune Boosting
- Inflammation Resolution
- Neuroprotection
- Cardioprotection
- US status
- Research Chemical / Compounded Medication
- Approval
- Not FDA approved as a drug. Has Orphan Drug Designation for pulmonary arterial hypertension.
- Evidence
- Human studies for various conditions including chronic inflammatory response syndrome (CIRS), with ongoing research for diabetes and PCOS.
- Research score
- 80 / 100
- Indication
- Investigational - Inflammatory Conditions, Diabetes, PCOS
- Origin
- USA
- Source category
- Digestive System
- Status group
- Research chemical
Mechanism
Binds VPAC1/VPAC2 receptors to raise cAMP and activate PKA, suppressing pro-inflammatory cytokines while boosting anti-inflammatory IL-10; relaxes gut smooth muscle and regulates intestinal secretion and barrier integrity, and shows neuroprotective effects via PI3K/Akt while dampening NF-κB-driven inflammation in immune cells.
Safety file
Generally considered safe, particularly as a compounded nasal spray.
- Flushing
- Hypotension
- Diarrhea
- Nausea
- Dizziness