Library · Metabolic & weight · Research of metabolic disorders
JBSNF-000088 (6-Methoxynicotinamide)
6-Methoxy-3-pyridinecarboxamide, 6-Methoxynicotinic acid amide, 6-MNA
Orally active small-molecule inhibitor of nicotinamide N-methyltransferase (NNMT), not a peptide. A 2018 study in obese mice found it reduced body weight, improved insulin sensitivity, and normalized glucose tolerance; remains a research compound.
Research score 50/100. Reference only, not a dose.
- Metabolic Enhancement
- Insulin Regulation
- Weight Loss
- US status
- Research Chemical
- Approval
- Not FDA Approved
- Evidence
- Preclinical animal studies only.
- Research score
- 50 / 100
- Indication
- Research Only - No Medical Indication
- Origin
- Japan
- Source category
- Metabolic & Weight Management
- Status group
- Research chemical
Mechanism
Blocks NNMT, lowering levels of the byproduct 1-methylnicotinamide, which in animal models is linked to improved insulin sensitivity, glucose control, and lower body weight.
Safety file
Limited data; research use only, with no human safety data available.
- Unknown in humans