Healing & recovery · Anti-inflammatory peptide for skin and gut models
KPV
α-MSH 11-13, Ac-Lys-Pro-Val
The C-terminal tripeptide of α-MSH (lysine-proline-valine). Studied in skin and gut: anti-inflammatory and antimicrobial models (colitis, psoriasis, wounds) without steroid-style immunosuppression.
- Anti-inflammatory
- Skin health
- Wound healing
- Catalog fill
- 10 mg
- Typical water
- 2 mL
- Route
- Subcutaneous
- Cycle
- 2–4 weeks.
- Approval
- Research chemical only.
- Status
- Research chemical.
- Evidence
- Preclinical work and limited topical/oral experimental use.
- Research score
- 60 / 100
Mechanism
Melanocortin-receptor-independent. Cuts IL-1β, TNF-α, IL-6 and damps NF-κB in keratinocytes and immune cells.
Safety file
Mild topical irritation and mild GI upset when taken orally in the available reports. No long-term human file.
- Mild skin irritation (topical)
- Mild GI upset (oral)
Reconstitution
2 mL bacteriostatic water into 10 mg gives 5 mg/mL, 50 mcg/unit. A 250 mcg amount is 5 units.
Research amounts
Once daily.
| Step | Amount | Frequency | Notes |
|---|---|---|---|
| Common range | 200–250 mcg | Once daily | — |
| Upper cited range | 500 mcg | Once daily | — |
Storage
- Lyophilized
- −20 °C freezer preferred; a refrigerator is also acceptable. Do not open a cold vial — wait 15–30 minutes so it does not sweat. Avoid freeze–thaw cycling.
- After water
- 2–8 °C, dark, up to 45 days when mixed with bacteriostatic water. Mixed vials stay in their box. Sterile water (no preservative) is single-use.
Worksheet notes
- Also a component of KLOW. Do not stack a full KPV vial on top of KLOW without accounting for the overlap.
- Bacteriostatic water: 20–25 °C. Do not refrigerate the diluent.
- Amounts on this sheet are reconstitution math for the vial, not a recommendation.
Full protocol
Titration, schedule, and handling
The complete protocol for KPV. Where it differs from the worksheet amounts above, the worksheet reflects the NovaEvum vial.
Reconstitution
| Vial | 2 mL water | 3 mL water |
|---|---|---|
| 10 mg | 5 mg/mL | 3.33 mg/mL |
- Use bacteriostatic water as the diluent.
- Add the water slowly, letting it run down the inside wall of the vial rather than onto the powder.
- Swirl gently to mix, then leave it to dissolve. Do not shake.
- Give it a few minutes. The finished solution should be clear and colourless.
Protocol
Route: Subcutaneous
Standard protocol (subcutaneous)
- 0.5 mg (500 mcg) once daily is the common working dose
- Some start at 0.2 mg to gauge response
- For gut-focused use it is often run daily through an active flare
Dosing detail
- Common daily dose is around 0.2 mg to 0.5 mg, with 0.5 mg the typical working amount.
- Once daily subcutaneous is the usual approach.
- Often used in shorter courses during an active inflammatory or gut issue rather than continuously.
- Community dosing data for KPV is thinner than for BPC-157 or TB-500, so start conservative and assess.
Duration
- Typically a 2 to 4 week course around an inflammatory issue, then stop or taper. Repeat as needed around flares.
Notes
- An anti-inflammatory tripeptide, popular for gut inflammation and skin issues.
- Generally well tolerated.
- Rotate sites.
Storage and handling
- Keep the powdered (lyophilized) vial in a cool, dark place. Refrigerate it for longer-term storage before mixing.
- Once reconstituted and refrigerated at 2–8 °C away from light, use the vial within 90 days.
- Do not freeze a reconstituted vial, and keep it away from heat and sunlight.
- If the solution turns cloudy, develops floating particles, or shows any other sign of degradation, stop using that vial.