Library · Skin & hair · Reduction of expression wrinkles and fine lines
Argireline (Acetyl Hexapeptide-3 / Acetyl Hexapeptide-8)
Acetyl Hexapeptide-3, Acetyl Hexapeptide-8, Argireline, Ac-Glu-Glu-Met-Gln-Arg-Arg-NH2
Synthetic hexapeptide from Lipotec (2001), designed as a topical, non-injectable alternative to botulinum toxin. Mimics part of SNAP-25 to soften expression wrinkles; used widely in cosmetics, with effects reported milder than injectable neurotoxins.
Research score 65/100. Reference only, not a dose.
- Skin Health
- Anti-aging
- Collagen Production
- Wrinkle Reduction
- US status
- Research Chemical
- Approval
- Cosmetic Use Only
- Evidence
- Limited Human Studies
- Research score
- 65 / 100
- Indication
- Cosmetic/Anti-aging
- Origin
- Spain
- Source category
- Skin & Dermatology
- Status group
- Research chemical
Mechanism
Competitively blocks SNAP-25 from joining the SNARE complex, reducing acetylcholine release at neuromuscular junctions and dampening the muscle contractions that form expression lines.
Safety file
Considered good; well tolerated in cosmetic use.
- Well-tolerated with minimal side effects