Library · Skin & hair · Skin rejuvenation and anti-aging treatment
Matrixyl (Palmitoyl Pentapeptide-3/4) & Matrixyl 3000 (Pal-GHK + Pal-GQPR/Rigin)
Palmitoyl Pentapeptide-3, Pal-KTTKS, Palmitoyl Tripeptide-1, Palmitoyl Tetrapeptide-7, Pal-GHK, Pal-GQPR, Rigin
Synthetic peptide complexes (Palmitoyl Pentapeptide-3/4, and enhanced Matrixyl 3000) developed by Sederma, launched starting 2000, designed to mimic skin’s natural repair processes. Boosts collagen and matrix protein production, shown to reduce wrinkle depth and improve texture; a cosmetic ingredient rather than a drug.
Research score 65/100. Reference only, not a dose.
- Skin Health
- Collagen Production
- Anti-aging
- Wound Healing
- Antioxidant
- US status
- Research Chemical
- Approval
- Cosmetic Use Only
- Evidence
- Limited Human Studies
- Research score
- 65 / 100
- Indication
- Cosmetic/Anti-aging
- Origin
- France
- Source category
- Skin & Dermatology
- Status group
- Research chemical
Mechanism
The palmitoyl group aids skin penetration, then activates fibroblasts via TGF-β/SMAD signaling to raise collagen I/III/IV, fibronectin, and hyaluronic acid; in Matrixyl 3000, Pal-GHK drives copper-dependent collagen cross-linking while Rigin modulates IL-6 and inflammation.
Safety file
Good.
- Well-tolerated with minimal side effects