Library · Brain & nerves · Cognitive enhancement and neuroprotection
Cortagen (Ala-Glu-Asp-Pro)
Ala-Glu-Asp-Pro, AEDP peptide, Cortagen tetrapeptide
Synthetic tetrapeptide (Ala-Glu-Asp-Pro), one of the Russian “Khavinson peptides,” developed for cognitive support and neuroprotection. Suggested in research to preserve cognition under stress and aid memory through effects on neurotransmitters and neuroplasticity; not FDA-approved, with limited human study.
Research score 50/100. Reference only, not a dose.
- Cognitive Enhancement
- Neuroprotective
- Memory Enhancement
- Focus Enhancement
- Stress Relief
- US status
- Research Chemical
- Approval
- Not FDA Approved
- Evidence
- Limited to preclinical studies. No significant human clinical trials.
- Research score
- 50 / 100
- Indication
- Cognitive Enhancement (Research)
- Origin
- Russia
- Source category
- Brain & Nervous System
- Status group
- Research chemical
Mechanism
Thought to mimic ACTH fragments and modulate neural gene expression via cAMP/PKA signaling and NMDA receptor activity, while promoting BDNF and reducing inflammatory cytokines and oxidative stress in neural tissue.
Safety file
Generally well tolerated in animal studies; human safety data is very limited.
- Mild headache
- Nausea
- Drowsiness