Library · Brain & nerves · Cognitive enhancement and neuroprotection
Dihexa
PNB-0408, N-hexanoyl-tyrosyl-isoleucyl-6-aminohexanoic acid amide
Synthetic peptide from Washington State University (2012), built from a modified angiotensin IV to improve stability and brain penetration. Acts as an HGF mimetic promoting nerve growth and connections; studied preclinically for cognitive decline and neurodegeneration, but remains unapproved with limited human data.
Research score 55/100. Reference only, not a dose.
- Cognitive Enhancement
- Memory Enhancement
- Neuroprotection
- Neurogenesis
- BDNF Increase
- US status
- Research Chemical
- Approval
- Research Chemical Only
- Evidence
- Angiotensin IV analog and HGF/c-Met activator. Promotes synaptogenesis and neurogenesis. Investigated for neurodegenerative diseases.
- Research score
- 55 / 100
- Indication
- Research Only - No Medical Indication
- Origin
- USA
- Source category
- Brain & Nervous System
- Status group
- Research chemical
Mechanism
Agonizes the c-Met receptor, activating MAPK and PI3K/Akt signaling that drives neurogenesis, synapse formation, and dendritic spine growth, while raising BDNF expression.
Safety file
Human safety is unknown; theoretical cancer risk from activating the c-Met oncogenic pathway, and possible overstimulation, anxiety, or irritability.
- Headache
- Nausea
- Dizziness
- Anxiety
- Sleep changes