Library · Brain & nerves · Sleep regulation and stress reduction
DSIP (Delta Sleep-Inducing Peptide)
DSIP, Deltaran, Trp-Ala-Gly-Gly-Asp-Ala-Ser-Gly-Glu
Naturally occurring nonapeptide discovered in 1977 in rabbit brain tissue during sleep research. Studied for effects on sleep regulation, stress reduction, and pain modulation via GABA and serotonin pathways; remains an unapproved research compound with limited clinical evidence.
Research score 60/100. Reference only, not a dose.
- Sleep Improvement
- Stress Relief
- Anxiety Reduction
- Circadian Regulation
- Pain Relief
- US status
- Research Chemical
- Approval
- Research Chemical Only
- Evidence
- Neuropeptide with sleep-promoting and stress-reducing properties. Clinical efficacy remains inconsistent.
- Research score
- 60 / 100
- Indication
- Research Only - No Medical Indication
- Origin
- Switzerland
- Source category
- Brain & Nervous System
- Status group
- Research chemical
Mechanism
Enhances GABA receptor activity and adenosine signaling in sleep-regulating brain regions, dampens the HPA stress axis to lower cortisol, and interacts with the suprachiasmatic nucleus to shape circadian and delta-wave sleep patterns.
Safety file
Long-term human safety unknown; grogginess and headache reported anecdotally, with an FDA warning about serious immune reactions from compounded versions and possible interaction with other sedatives.
- Drowsiness
- Headache
- Injection site reactions
- Temporary changes in appetite