Library · Brain & nerves · Anti-aging and circadian rhythm regulation
N-Acetyl Epithalon Amidate
N-Acetyl Epithalon Amide, N-Ac-AEDG-NH2, N-Acetyl Epitalon Amidate
A 2000s modified version of Epithalon carrying an acetyl and amidate group meant to improve stability and bioavailability. It targets pineal function and melatonin output and is studied for telomerase activity, circadian regulation, and cellular repair, though human evidence is lacking and it remains a research compound.
Research score 60/100. Reference only, not a dose.
- Anti-aging
- Circadian Regulation
- Neuroprotection
- DNA Repair
- Telomere Protection
- US status
- Research Chemical
- Approval
- Research Chemical Only
- Evidence
- Modified version of Epitalon with improved stability and blood-brain barrier penetration. Investigated for anti-aging, sleep regulation, and telomere maintenance.
- Research score
- 60 / 100
- Indication
- Research Only - No Medical Indication
- Origin
- Russia
- Source category
- Brain & Nervous System
- Status group
- Research chemical
Mechanism
Stimulates melatonin release from pinealocytes and SIRT1 expression, activates telomerase via hTERT upregulation, adjusts clock genes in the suprachiasmatic nucleus, and raises antioxidant enzymes for neuroprotection.
Safety file
Tolerability is inferred from Epithalon data and appears reasonable short term, but long-term safety and a theoretical telomerase-linked cancer risk are unknown; not FDA approved.
- Injection site reactions
- Fatigue
- Headache