Library · Brain & nerves · Cognitive enhancement and neuroprotection
PE-22-28
PE 22-28, Proline-Glutamate peptide fragment 22-28, PE22-28
A synthetic derivative of the spadin peptide that blocks TREK-1 channels, studied for possible antidepressant effects through stimulating neurogenesis and mood regulation. It remains a research chemical with no human trial data.
Research score 40/100. Reference only, not a dose.
- Cognitive Enhancement
- Neuroprotective
- Memory Enhancement
- BDNF Increase
- Focus Enhancement
- US status
- Research Chemical
- Approval
- Research Chemical Only
- Evidence
- Preclinical only. No significant human clinical trials found.
- Research score
- 40 / 100
- Indication
- Research Only - No Medical Indication
- Origin
- USA
- Source category
- Brain & Nervous System
- Status group
- Research chemical
Mechanism
Crosses the blood-brain barrier to engage BDNF/TrkB signaling, promoting synaptic plasticity, dendritic growth, and long-term potentiation, aided by cAMP/PKA activity and reduced oxidative and inflammatory markers.
Safety file
No human safety data exist; animal studies suggest low toxicity but possible CNS effects such as sedation or irritability.
- Mild headache
- Nasal irritation
- Temporary dizziness
- Fatigue