Library · Brain & nerves · Cognitive enhancement and neuroprotection
Pinealon (Glu-Asp-Arg)
EDR peptide, Glu-Asp-Arg, Pinealon bioregulator
A 1990s Russian-developed tripeptide (Glu-Asp-Arg) designed to cross the blood-brain barrier and support cognition and neuroprotection. Animal studies suggest memory and learning benefits, but research remains mostly confined to Russia and Eastern Europe with limited human trials.
Research score 70/100. Reference only, not a dose.
- Cognitive Enhancement
- Neuroprotection
- Memory Enhancement
- Focus Enhancement
- BDNF Increase
- US status
- Research Chemical
- Approval
- Research Chemical Only
- Evidence
- Short peptide bioregulator (tripeptide). Investigated for neuroprotective effects and gene expression modulation.
- Research score
- 70 / 100
- Indication
- Cognitive Enhancement (Research)
- Origin
- Russia
- Source category
- Brain & Nervous System
- Status group
- Research chemical
Mechanism
Stimulates BDNF expression and TrkB signaling, engaging PI3K/Akt and MAPK/ERK pathways for neuron survival and plasticity, while helping regulate calcium balance, oxidative stress, and genes tied to neuroplasticity.
Safety file
Appears benign in available studies; possible mild effects include vivid dreams, GI upset, or mood shifts; long-term human data are limited.
- Headache
- Mild dizziness
- Nasal irritation