Library · Brain & nerves · Neuroprotection and neural development regulation
PTD-DBM
PTD-Dishevelled Binding Motif, Protein Transduction Domain-DBM, PTD-DBM peptide
A synthetic peptide designed to activate Wnt/β-catenin signaling by blocking CXXC5, studied mainly for hair regrowth and wound-triggered hair regeneration, often applied topically alongside valproic acid.
Research score 40/100. Reference only, not a dose.
- Neuroprotective
- Cognitive Enhancement
- BDNF Increase
- Neurogenesis
- US status
- Research Chemical
- Approval
- Research Chemical Only
- Evidence
- Preclinical only. No confirmed human trials (2020-2025).
- Research score
- 40 / 100
- Indication
- Research Only - No Medical Indication
- Origin
- USA
- Source category
- Brain & Nervous System
- Status group
- Research chemical
Mechanism
A cell-penetrating domain lets it reach the nucleus, where it disrupts Smad1 interactions to influence BMP signaling, raising BDNF and supporting neuron survival, plasticity, and reduced oxidative and inflammatory stress in neural tissue.
Safety file
Human safety data are lacking; sold as a 'cosmetic' in some markets; theoretical cancer risk tied to Wnt pathway activation.
- Nasal irritation
- Headache
- Dizziness
- Fatigue