Library · Brain & nerves · Cognitive enhancement and neuroprotection
Semax
ACTH(4-7)Pro-Gly-Pro, Met-Glu-His-Phe-Pro-Gly-Pro, MEHFPGP
A Russian- and Eastern European-used synthetic heptapeptide derived from ACTH(1-7), valued for nootropic, neuroprotective, and neurorestorative effects via BDNF upregulation and neurotransmitter modulation. Approved clinically in Russia; a research chemical in the US, EU, and most other markets.
Research score 75/100. Reference only, not a dose.
- Cognitive Enhancement
- Neuroprotective
- Memory Enhancement
- Focus Enhancement
- BDNF Increase
- US status
- Research Chemical
- Approval
- Approved as prescription drug in Russia and Eastern Europe; Not FDA Approved in US/EU.
- Evidence
- Limited Human Studies
- Research score
- 75 / 100
- Indication
- Nootropic, Neuroprotective (in Russia).
- Origin
- Russia
- Source category
- Brain & Nervous System
- Status group
- Research chemical
Mechanism
Offers greater stability and brain penetration than natural ACTH(4-10), raising BDNF/TrkB signaling and serotonin/dopamine levels while regulating glutamate; activates MAPK/ERK to support synaptic growth and neuron survival, and lowers inflammatory cytokines and oxidative stress in the CNS.
Safety file
Generally well tolerated; most side effects are mild and tied to nasal use; may raise blood glucose in diabetics; not for use in pregnancy or breastfeeding; long-term effects largely unknown.
- Nasal irritation
- Burning sensation
- Congestion
- Runny nose
- Headaches
- Insomnia
- Increased anxiety
- Nausea
- Dizziness