Library · Immune · Diagnostic testing of adrenal gland function
Cosyntropin (Tetracosactide)
Synacthen, Cortrosyn, Tetracosactrin, ACTH(1-24)
Synthetic ACTH analog (first 24 amino acids) from the 1960s, used as the gold-standard diagnostic test for adrenal function under brand names Synacthen and Cortrosyn. Some research also explores therapeutic use in certain autoimmune conditions.
Research score 85/100. Reference only, not a dose.
- Hormone Regulation
- Anti-inflammatory
- Immune Boosting
- Inflammation Resolution
- US status
- Prescription Only
- Approval
- FDA + EMA Approved
- Evidence
- Extensive Human Studies
- Research score
- 85 / 100
- Indication
- Diagnostic Agent
- Origin
- Switzerland
- Source category
- Immune System
- Status group
- Approved / prescription
Mechanism
Binds melanocortin-2 receptors on adrenal cortex cells, raising cAMP and PKA activity that mobilizes cholesterol via StAR protein regulation, driving cortisol and other adrenal steroid synthesis.
Safety file
Good.
- Allergic reactions
- Temporary dizziness
- Facial flushing
- Local injection site reactions
- Nausea