Library · Skin & hair · Regulation of skin pigmentation and melanin production
Nonapeptide-1 (Melanostatin-5)
Melanostatin-5, Melanostatine-5, Met-Pro-D-Phe-Arg-Trp-Phe-Lys-Pro-Val-NH2
Also called Melanostatin-5, this biomimetic peptide blocks α-MSH from binding MC1R, curbing melanin production. It is used in cosmetic formulations to address hyperpigmentation and even out skin tone.
Research score 70/100. Reference only, not a dose.
- Skin Health
- Melanin Production
- Photoprotection
- Anti-inflammatory
- US status
- Research Chemical
- Approval
- Cosmetic Use Only
- Evidence
- Clinical studies on skin lightening/radiance (2020-2025). Used for hyperpigmentation.
- Research score
- 70 / 100
- Indication
- Skin Pigmentation Disorders
- Origin
- USA
- Source category
- Skin & Dermatology
- Status group
- Research chemical
Mechanism
Competitively blocks α-MSH at MC1R, lowering cAMP and tyrosinase activity to cut melanin synthesis, while also damping inflammatory cytokine and NF-κB signaling in skin cells.
Safety file
Well tolerated on skin; no major risks identified in cosmetic use.
- Mild skin irritation
- Temporary redness
- Contact dermatitis in sensitive individuals