Library · Skin & hair · Topical anti-aging and skin rejuvenation
OS-01
OS-01 peptide, Ontogenetic Signal 1, OneSkin peptide
A synthetic peptide developed in 2019 for topical skincare, aimed at senescent skin cells and barrier health. Lab research suggests it activates longevity pathways, boosts collagen, and supports the skin barrier; it is sold in cosmetic lines but lacks large clinical trials.
Research score 85/100. Reference only, not a dose.
- Skin Health
- Anti-aging
- Collagen Production
- DNA Repair
- Inflammation Resolution
- US status
- Research Chemical
- Approval
- Cosmetic Use Only
- Evidence
- Validated for skin rejuvenation and barrier repair. Shown to be safe for sensitive skin (eczema friendly) and effective in reducing cellular senescence markers.
- Research score
- 85 / 100
- Indication
- Cosmetic/Anti-aging
- Origin
- USA
- Source category
- Skin & Dermatology
- Status group
- Research chemical
Mechanism
Regulates genes tied to skin barrier function and cellular senescence, lowering SASP factors while boosting autophagy and activating SIRT1/AMPK signaling to improve mitochondrial function and support ceramide and tight-junction gene expression.
Safety file
Strong topical safety profile with no reported systemic absorption; rare mild dryness or irritation; considered non-genotoxic.
- Well-tolerated with minimal side effects