Library · Skin & hair · Skin rejuvenation and collagen production
Pal-AHK (Palmitoyl Tripeptide-3)
Palmitoyl Tripeptide-3, Pal-AHK, Palmitoyl-Ala-His-Lys, Biopeptide CL
A 1990s lipopeptide combining palmitic acid with a three-amino-acid sequence, developed for cosmetic anti-aging use. Marketed under names like Biopeptide CL to stimulate collagen and reduce fine lines, with cosmetic-level safety data but no therapeutic status.
Research score 38/100. Reference only, not a dose.
- Skin Health
- Collagen Production
- Anti-aging
- Wound Healing
- US status
- Research Chemical
- Approval
- Cosmetic Use Only
- Evidence
- Limited Human Studies
- Research score
- 38 / 100
- Indication
- Cosmetic/Anti-aging
- Origin
- France
- Source category
- Skin & Dermatology
- Status group
- Research chemical
Mechanism
The palmitoyl tail aids skin penetration while the AHK sequence engages fibroblast receptors, activating SMAD-dependent TGF-β signaling to raise collagen gene expression and block collagen-degrading enzymes, alongside PI3K/Akt-driven fibroblast migration.
Safety file
Good tolerability profile.
- Well-tolerated with minimal side effects