Library · Skin & hair · Skin rejuvenation and collagen production enhancement
Palmitoyl Dipeptide-6
Pal-KT, Palmitoyl-Lys-Thr, Hexadecanoyl-Lysine-Threonine
An early-2000s cosmetic peptide pairing two amino acids with palmitic acid to boost skin penetration and fibroblast collagen output. Used in premium skincare, though most evidence comes from manufacturer-backed studies.
Research score 60/100. Reference only, not a dose.
- Skin Health
- Collagen Production
- Anti-aging
- Wound Healing
- US status
- Research Chemical
- Approval
- Cosmetic Use Only
- Evidence
- Used in cosmetic formulations for skin conditioning and barrier support. Exact clinical efficacy data for this specific sequence is sparse compared to Matrixyl peptides.
- Research score
- 60 / 100
- Indication
- Cosmetic/Anti-aging
- Origin
- France
- Source category
- Skin & Dermatology
- Status group
- Research chemical
Mechanism
Engages fibroblast receptors to trigger TGF-β/SMAD signaling, raising Type I and III collagen while regulating matrix-degrading enzymes and showing mild anti-inflammatory NF-κB effects.
Safety file
Considered safe for cosmetic use at typical concentrations; no specific toxicology concerns reported.
- Well-tolerated with minimal side effects