Library · Skin & hair · Skin elasticity and anti-aging enhancement
Lipopeptide (Biopeptide EL / Palmitoyl Hexapeptide-12)
Biopeptide EL, Palmitoyl Hexapeptide-12, Palmitoyl-VGVAPG, Sederma Biopeptide EL
A Sederma lipopeptide from the early 2000s, marketed as Biopeptide EL, combining palmitic acid with a six-amino-acid sequence to improve skin absorption. It signals fibroblasts to raise collagen and elastin for better elasticity, though evidence is mostly company-sponsored.
Research score 38/100. Reference only, not a dose.
- Skin Health
- Collagen Production
- Anti-aging
- Wound Healing
- US status
- Research Chemical
- Approval
- Cosmetic Use Only
- Evidence
- Limited Human Studies
- Research score
- 38 / 100
- Indication
- Cosmetic/Anti-aging
- Origin
- France
- Source category
- Skin & Dermatology
- Status group
- Research chemical
Mechanism
Engages TGF-β/SMAD signaling to raise collagen, elastin, and glycosaminoglycan output, while boosting integrin-mediated cell-matrix adhesion and guarding against matrix-degrading enzymes.
Safety file
Good tolerability profile.
- Well-tolerated with minimal side effects