Library · Skin & hair · Skin rejuvenation and anti-aging treatment
Palmitoyl Pentapeptide-4
Palmitoyl Pentapeptide-3, Pal-KTTKS, Palmitoyl Tripeptide-1, Palmitoyl Tetrapeptide-7, Pal-GHK, Pal-GQPR, Rigin
Known commercially as Matrixyl, and combined with other peptides in Matrixyl 3000, this cosmetic peptide mimics natural skin-repair signals to raise collagen and other matrix proteins. Studies show reduced wrinkle depth and improved texture, though it remains a cosmetic rather than pharmaceutical ingredient.
Research score 95/100. Reference only, not a dose.
- Skin Health
- Collagen Production
- Anti-aging
- Wound Healing
- Antioxidant
- US status
- Research Chemical
- Approval
- Cosmetic Use Only
- Evidence
- The 'Gold Standard' anti-aging peptide. Stimulates collagen I, III, IV and fibronectin. Validated in numerous clinical studies for wrinkle reduction.
- Research score
- 95 / 100
- Indication
- Cosmetic/Anti-aging
- Origin
- Various
- Source category
- Skin & Dermatology
- Status group
- Research chemical
Mechanism
Penetrates via its palmitoyl tail and drives TGF-β/SMAD-dependent fibroblast activation, raising Collagen I, III, and IV, fibronectin, and hyaluronic acid; in the 3000 blend, added Pal-GHK and Rigin support collagen cross-linking and calm inflammation.
Safety file
Strong safety record; non-toxic, non-mutagenic, and non-carcinogenic, with minimal systemic absorption.
- Well-tolerated with minimal side effects