Library · Skin & hair · Reduction of expression lines and wrinkles
Pentapeptide-18 (Leuphasyl)
Leuphasyl, YdAGFL-NH2, Tyr-D-Ala-Gly-Phe-Leu-NH2
Known as Leuphasyl, this early-2000s cosmetic peptide was designed as a gentler alternative to botulinum toxin for reducing expression lines, often combined with Argireline. Manufacturer studies show reduced muscle-contraction intensity, but independent clinical research is limited.
Research score 35/100. Reference only, not a dose.
- Skin Health
- Anti-aging
- Collagen Production
- Wrinkle Reduction
- US status
- Research Chemical
- Approval
- Cosmetic Use Only
- Evidence
- Limited Human Studies
- Research score
- 35 / 100
- Indication
- Cosmetic/Anti-aging
- Origin
- Spain
- Source category
- Skin & Dermatology
- Status group
- Research chemical
Mechanism
Mimics enkephalins to bind nerve-terminal receptors and reduce acetylcholine release, interfering with SNARE-complex-driven vesicle fusion and thereby lowering the frequency and force of facial muscle contractions.
Safety file
Good tolerability profile.
- Well-tolerated with minimal side effects