Library · Skin & hair · Topical anti-aging and wrinkle reduction
Syn-AKE (Dipeptide Diaminobutyroyl Benzylamide Diacetate)
Syn-AKE, Snake Tripeptide, Dipeptide-15, Diaminobutyroyl Benzylamide Diacetate
A 2006 synthetic tripeptide mimicking Waglerin-1 from temple viper venom, designed as a safer topical alternative to botulinum toxin for facial lines. Studies report up to about 52% reduced wrinkle depth after 28 days, though evidence is largely from cosmetic trials rather than rigorous clinical research.
Research score 35/100. Reference only, not a dose.
- Skin Health
- Anti-aging
- Collagen Production
- Muscle Growth
- US status
- Research Chemical
- Approval
- Cosmetic Use Only
- Evidence
- Limited Human Studies
- Research score
- 35 / 100
- Indication
- Cosmetic/Anti-aging
- Origin
- Switzerland
- Source category
- Skin & Dermatology
- Status group
- Research chemical
Mechanism
Reversibly blocks nicotinic acetylcholine receptors at the neuromuscular junction, reducing acetylcholine-driven muscle contraction and calcium channel activity, producing temporary muscle relaxation without full paralysis; also supports dermal matrix protein synthesis.
Safety file
Good tolerability profile.
- Well-tolerated with minimal side effects