Library · Skin & hair · Stimulation of collagen synthesis in skin
Syn-Coll (Palmitoyl Tripeptide-5)
Syn-Coll, Palmitoyl-Lys-Val-Lys, Pal-KVK, Collagen Tripeptide
Known as Palmitoyl Tripeptide-5, this early-2000s cosmetic peptide mimics the body's TGF-β-driven collagen production pathway. Lab studies show increased collagen output and organization in skin fibroblasts, though evidence is mainly from manufacturer-sponsored research.
Research score 38/100. Reference only, not a dose.
- Collagen Production
- Skin Health
- Anti-aging
- Wound Healing
- US status
- Research Chemical
- Approval
- Cosmetic Use Only
- Evidence
- Limited Human Studies
- Research score
- 38 / 100
- Indication
- Cosmetic/Anti-aging
- Origin
- Spain
- Source category
- Skin & Dermatology
- Status group
- Research chemical
Mechanism
Mimics TGF-β's receptor-binding domain to trigger SMAD2/3 phosphorylation and nuclear translocation, raising transcription of collagen genes COL1A1 and COL3A1, and helping regulate matrix-degrading enzymes; its palmitoyl tail aids skin penetration.
Safety file
Good tolerability profile.
- Well-tolerated with minimal side effects