Library · Skin & hair · Skin rejuvenation and collagen production enhancement
Tripeptide-29 (Collagen peptide)
Gly-Pro-Hyp, GPH tripeptide, Collagen tripeptide, Tripeptide-29
Also known as Gly-Pro-Hyp, this synthetic peptide mimics a building block of natural collagen and is used in cosmetics and oral collagen supplements to support skin elasticity, hydration, and matrix strength.
Research score 65/100. Reference only, not a dose.
- Skin Health
- Collagen Production
- Anti-aging
- Wound Healing
- Antioxidant
- US status
- Cosmetic Ingredient / Dietary Supplement
- Approval
- Not an approved drug. Widely used in cosmetics and as a GRAS dietary supplement.
- Evidence
- Human clinical trials for both topical and oral use have shown statistically significant improvements in skin wrinkles, elasticity, and hydration.
- Research score
- 65 / 100
- Indication
- Cosmetic/Anti-aging
- Origin
- Japan
- Source category
- Skin & Dermatology
- Status group
- Cosmetic / other
Mechanism
Stimulates dermal fibroblasts through TGF-β/SMAD signaling to raise Type I and III collagen genes while regulating matrix-degrading enzymes; also reduces buildup of advanced glycation end products, may inhibit DPP-IV, and drives fibroblast growth and migration via ERK1/2 signaling to support wound healing.
Safety file
Considered excellent for both topical and oral use.
- Well-tolerated with minimal side effects