Library · Skin & hair · Reduction of facial wrinkles and expression lines
Vialox (Pentapeptide-3V)
Pentapeptide-3V, Syn-Ake, Acetyl-GPRPA-NH2
Marketed sometimes as Syn-Ake, this early-2000s cosmetic peptide mimics Waglerin-1 from temple viper venom to relax facial muscles topically, targeting expression lines. Lab studies show it can reduce muscle-cell contraction, though it remains a cosmetic rather than pharmaceutical ingredient.
Research score 35/100. Reference only, not a dose.
- Skin Health
- Anti-aging
- Collagen Production
- Muscle Growth
- US status
- Research Chemical
- Approval
- Cosmetic Use Only
- Evidence
- Limited Human Studies
- Research score
- 35 / 100
- Indication
- Cosmetic/Anti-aging
- Origin
- Switzerland
- Source category
- Skin & Dermatology
- Status group
- Research chemical
Mechanism
Reversibly binds the nicotinic acetylcholine receptor at the neuromuscular junction, blocking acetylcholine from triggering contraction and interfering with SNARE-complex-driven neurotransmitter release, producing a localized, reversible reduction in the micro-contractions that form expression lines.
Safety file
Good tolerability profile.
- Well-tolerated with minimal side effects